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A world-first international study led by the University of South Australia has identified a new drug to stop athletes developing dementia after sustaining repeated head injuries in their career.
The link between concussion and neurogenerative diseases is well established, but new research findings could halt the progression of chronic traumatic encephalopathy. CTE is a progressive and fatal brain disease associated with the accumulation of a protein known as hyperphosphorylated tau which affects cognition and behaviour.
In a paper published in Scientific Reports, UniSA Emeritus Professor Bob Vink and colleagues show how repeated concussions can cause CTE and a way to block it with a specially developed drug.
The findings will potentially have significant implications for athletes who play contact sports -- such as boxers and footballers -- as well as military veterans sustaining head injuries in conflict.
The team of researchers from Adelaide, Melbourne and the United States say the brain releases a neurotransmitter called substance P in the event of a head injury, causing abnormal amounts of the tau protein to collect inside neurons.
"Our research shows that by blocking substance P with a specific drug, we can prevent the tau protein tangles from developing in the brain and causing neurological problems."
The treatment was successfully tested in animal models, giving hope that CTE can be prevented in humans.
Prof Vink says the next step is human clinical trials, but that could take several years given that currently CTE can only be diagnosed post-mortem.
By Аvera Allen | Linkedin
#News #Health #Medical #dementia #Whealthnews
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